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Highlight sequence clc sequence viewer5/28/2023 ![]() The involvement of IL-17 in mucosal immune responses could be conserved in higher vertebrates from these ancestral lineages.Ĭonserved innate immunity mechanisms based on nonself recognition, signal transduction and immune gene activation are essential for effective protection against bacterial and viral invasions. Certain isoforms were specifically implicated in the response to a waterborne infection with Vibrio splendidus in mussel gills. Mussel IL-17 isoforms were conserved among individuals and shared between closely related Mytilidae species. We recovered 379 unique IL-17 sequences and 96 receptors from individual genomes that were classified into 23 and 6 isoforms after phylogenetic analyses. We further studied this expansion in filter-fed Mytilus galloprovincialis, which is a bivalve with a highly effective innate immune system supported by a variable pangenome. Large expansions of the IL-17 repertoire were observed in marine molluscs and echinoderm species. Cnidaria was highlighted as the most ancient diverged phylum, and several evolutionary patterns were revealed. A comparative genomics approach was applied to examine IL-17 throughout evolution from poriferans to higher vertebrates. The interleukin-17 (IL-17) family consists of proinflammatory cytokines conserved during evolution. 2Department of Biology, University of Padova, Padova, Italy.1Institute of Marine Research (IIM), National Research Council (CSIC), Vigo, Spain. ![]() Amaro Saco 1, Magalí Rey-Campos 1, Umberto Rosani 2, Beatriz Novoa 1 and Antonio Figueras 1* ![]()
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